Alzheimer's disease, a progressive neurodegenerative disorder, poses significant challenges for both patients and their caregivers. While there is currently no cure for Alzheimer's, researchers are exploring various avenues to manage its symptoms and enhance the overall well-being of affected individuals. One such avenue of interest is the potential use of Aloe Vera, a plant known for its diverse health benefits.
The results of a study were reported to the Journal of Alzheimer's Disease in 2012 by John Lewis from the University of Miami Miller School of Medicine and 11 additional authors.
Later in this article, we’ll discuss the significance of the conclusions of this study.
Understanding Alzheimer's Disease:
Alzheimer's disease is characterized by the accumulation of beta-amyloid plaques and tau tangles in the brain, leading to the gradual decline of cognitive functions. Additionally, inflammation and impaired immune responses play a role in the progression of the disease.
Aloe Vera and Cognitive Function:
Aloe Vera contains compounds with antioxidant properties, which may help combat oxidative stress. Oxidative stress is implicated in the development and progression of Alzheimer's disease.
Chronic inflammation is associated with neurodegenerative diseases, including Alzheimer's. Aloe Vera has anti-inflammatory properties that could potentially mitigate inflammation in the brain.
Some studies suggest that Aloe Vera may have neuroprotective effects, helping to safeguard brain cells from damage.
Aloe Vera and Immune Function:
Enhancing Immune Responses:
Aloe Vera has been studied for its immunomodulatory effects, meaning it may influence the activity of the immune system. A well-functioning immune system is crucial for overall health, including the ability to respond to infections that may impact cognitive function.
The anti-inflammatory properties of Aloe Vera extend to its potential benefits for immune system regulation. Aloe Vera may contribute to a more balanced immune response by reducing inflammation.
The Study: The Effect of an Aloe Polymannose Multinutrient Complex on Cognitive and Immune Functioning in Alzheimer's Disease
The Alzheimer's Study
The clinical trial was published in the Journal of Alzheimer’s Disease in 2013.
The study included 34 patients who averaged just short of 80 years old. Each participant had been diagnosed with Alzheimer’s for a minimum of one year, and had the disease for an average of three years. Their condition was characterized as moderate to severe. Most study participants also had varying comorbidities.
The dietary supplement was the only change made to the patient’s lives over the 12-month study period. No additional changes were made to their diet, physical activity, or behavior, and they continued taking any medications previously prescribed.
Participants checked in every three months throughout the study period for neuropsychological assessments. At 12 months, they had their blood drawn again to reassess their immune systems and markers of inflammation.
Following the cognitive assessments, participants were provided with an aloe polysaccharide nutrient complex containing polysaccharides, antioxidants, omega-3 fatty acids, and various phytonutrients. Over the course of 12 months, participants orally consumed one teaspoon (equivalent to 2.5 grams) of the complex four times a day.
Dr. Lewis and his research team discovered that over the 12-month period, individuals with Alzheimer's showcased notable and enduring enhancements in cognitive performance, as assessed by the ADAS-cog test at the nine- and 12-month milestones.
Additionally, there was a substantial improvement in overall immune function, accompanied by a decrease in inflammatory markers associated with reduced inflammation in the brain. Moreover, the participants demonstrated a remarkable 300 percent increase in the generation of adult stem cells, which is believed to contribute to restoring neuronal areas.
In regards to one of the inflammatory markers measured, the study reported:
“We also found a substantial drop in VEGF levels at the 12-month follow-up assessment. Others have suggested that VEGF might be linked to the progression of [Alzheimer’s disease] through abnormal endothelial activation, resulting in neuronal loss and [amyloid-beta] deposits.”
This groundbreaking study opens new possibilities for managing Alzheimer's symptoms by harnessing the potential of Aloe Vera. The observed cognitive improvements, enhanced immune function, and the increase in adult stem cells present a positive outlook, offering hope for future research and potential interventions in Alzheimer's disease.